Humpath.com - Human pathology

Home > E. Pathology by systems > Skin > cutaneous sarcoidosis

cutaneous sarcoidosis

Monday 23 May 2016

PO

Definition: Sarcoidosis has granulomas composed of histiocytes surrounded by lymphocytes, without necrosis.

Images

- cutaneous sarcoidosis

Microscopy

- Inflammatory and granulomatous reactions with dense superficial and deep lymphocytes, eosinophils and plasma cells
- Variable parakeratosis, spongiosis, acanthosis and epidermal erosion
- May have lymphoid germinal centers resembling lymphoma with destruction of adnexae and atypia
- Dense, noncaseating granulomatous infiltrate in the dermis extends into subcutaneous fat;

  • granulomas are discrete and uniform in size and shape;

- Variable Langhans giant cells, and scattered lymphocytes
- Discrete, small central foci of fibrinoid necrosis are present; also transepidermal elimination
- Schaumann bodies (calcium and protein inclusions inside of Langhans giant cells as part of a granuloma; basophilic laminated rounded conchoidal structures),
- asteroid bodies (small, intracytoplasmic, eosinophilic star shaped structure also present in tuberculoid leprosy, berylliosis and atypical facial necrobiotic xanthogranuloma),
- Hamazaki-Wesenberg bodies (peculiar PAS+ inclusions, may be large lysosomes containing hemolipofuscin)

Differential diagnosis

- cutaneous granulomatous diseases

See also

- sarcoidosis