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microcystic adnexal carcinoma

Wednesday 25 May 2016

MAC sclerosing sweat duct carcinoma

Definition : Microcystic adnexal carcinoma (MAC) is an uncommon cutaneous malignant neoplasm that is associated with significant morbidity in light of its propensity for local invasion. As implied by its names, MAC exhibits small keratinizing cysts and well-defined ducts.


- microcystic adnexal carcinoma :


- The tumor grows very slowly over the course of years
- thin bland cords & tubules : tadpoles / paisley tie pattern
- keratin cysts / keratin-filled microcysts
- well-defined ducts
- deeply infiltrative
- perineural infiltration (PNI)
- biphasic malignant sweat duct tumor with ductal and follicular differentiation
- bump or plaque on the upper lip, cheek or chin of older individuals

Differential diagnosis

- desmoplastic trichoepithelioma

See also

- cutaneous tumors

Open references

- Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature.
Chen J, Yang S, Chen J, Liao T, Deng W, Li W.
Oncol Lett. 2016 Apr;11(4):2471-2474.
PMID: 27073500 Free