- Human pathology

Home > E. Pathology by systems > Skin > eccrine spiradenoma

eccrine spiradenoma

Monday 30 May 2016


Definition: Spiradenoma forms a firm nodule on the face or upper trunk, and can be painful. The lesion is benign. Histologically it shows nests with two types of cells: small hyperchromatic cells at the periphery and larger and paler cells centrally. There is compact PAS+ eosinophilic basement membrane material and infiltrating lymphocytes.


- eccrine spiradenoma

- cystic eccrine spiradenoma

- eccrine spiradenoma nodule in the subcutis


- sharply circumscribed dermal nodule : " blue ball " appearance in dermis
- lobular architecture
- very cellular / high cellularity
- scant cytoplasm
- high vascularity
- variable lymphocytic infiltrate within lesion / interstitial lymphocytes
- hyaline globules
- biphasic appearance : light cells and dark cells / basophilic cells
- eosinophilic hyaline droplets
- presence of ducts / intratumoral ducts
- Can occur both separately and in combination with cylindromas
- blue nodula formation with peripheral small basaloid cells and larger paler cells centrally
- lobulated tumor islands separated by thin fibrous tissue containing blood vessels


- malignant eccrine spiradenoma


- CK7+ epithelial and p63+ myoepithelial cells

Differential diagnosis

- cutaneous lymphadenoma
- cutaneous cylindroma
- cutaneous metastatic carcinoma
- cutaneous synovial sarcoma
- cutaneous thymoma

See also

- cutaneous tumors