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penile intraepithelial neoplasia

Monday 30 May 2016

peIN, peIN1, peIN2, peIN3



- penile intraepithelial neoplasia and SCC

Penile intraepithelial neoplasia (PeIN ) has been coined to encompass the three preinvasive clinical entities of:

- penile Bowen disease
- erythroplasia of Queyrat
- bowenoid papulosis.


- Differentiated PeIN

  • Thickened epithelium with hyperkeratosis, parakeratosis, and
  • Elongated and anastomosing rete ridges
  • Subtle abnormal maturation (enlarged keratinocytes with
    abundant eosinophilic cytoplasm )
  • Keratin pearl formation
  • Prominent intercellular bridges (lack of cohesion )
  • Dysplastic hyperchromatic basal cells

- Basaloid PeIN

  • Epithelium replaced by a monotonous population of small to
    intermediate size blue cells with a high nuclear/cytoplasmic
  • Parakeratosis with a flat surface
  • Abundant mitotic figures and apoptosis
  • Isolated koilocytes in the superficial layers

- Warty PeIN

  • Thickened epithelium with an undulating and spiking surface
    and striking cellular pleomorphism
  • Atypical parakeratosis and dyskeratosis
  • Conspicuous koilocytosis (hyperchromatic wrinkled nuclei ,
    perinuclear halos , multinucleation )
  • Abundant mitoses

See also

- penile anomalies
- intraepithelial neoplasia (INs or IN )

See also

- penile tumors