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adenomyoepithelial adenosis

Tuesday 2 May 2017

apocrine adenosis; secretory adenosis


Definition: Uncommon variant of adenosis with proliferation of epithelial and myoepithelial cells. Adenomyoepithelial adenosis has prominent myoepithelial cells in 1-3 layers

Myoepithelial cells are widely present in the breast, and their hyperplasia may result in a spectrum of disease ranging from myoepitheliosis to myoepithelial carcinoma.


Although considered benign, adenomyoepithelial lesions tend to recur due to inadequate excision. Therefore, possibility of recurrence and even metastasis should be considered during follow-up of patients with a diagnosis of adenomyoepithelial lesions.

Open references

- Adenomyoepithelial Adenosis of the Breast: Clinical, Radiological, and Pathological Findings for Differential Diagnosis.
Erel S, Tuncbilek I, Kismet K, Kilicoglu B, Ozer E, Akkus MA.
Breast Care (Basel). 2008;3(6):427-430. Epub 2008 Nov 25.
PMID: 21048915 Free