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HPV-associated Bowen disease

Wednesday 8 June 2016

Orthokeratotic Bowen disease is a distinct variant of squamous cell carcinoma in situ associated with HPV infection in less than half of the cases studied (HPV-associated Bowen disease ). (26272630)

In contrast to anogenital HPV-associated lesions, positive p16 expression is not a reliable marker of high-risk α-HPV infection in Bowen disease cases, as it can be also detected in β-HPV infected and HPV-negative cases. (26913849)

See also

- cutaneous squamous cell carcinoma in situ ( Bowen disease )


- Human Papillomavirus Infection and p16 Expression in Extragenital/Extraungual Bowen Disease in Immunocompromised Patients. Švajdler M Jr, Mezencev R, Kašpírková J, Kacerovská D, Kazakov DV, Ondič O, Michal M. Am J Dermatopathol. 2016 Feb 24. PMID: 26913849

- Orthokeratotic Bowen disease: a histopathologic, immunohistochemical and molecular study. Idriss MH, Misri R, Böer-Auer A. J Cutan Pathol. 2016 Jan;43(1):24-31. doi : 10.1111/cup.12610 PMID: 26272630