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protein phosphatases

Monday 1 December 2003

Mitosis exit

The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell.

This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates.

Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases.

The key mitotic exit phosphatase in budding yeast, Cdc14, is now well understood.

By contrast, in animal cells, it is now emerging that mitotic exit relies on distinct regulatory networks, including the protein phosphatases PP1 and PP2A.

References

- Phosphatases: providing safe passage through mitotic exit. Wurzenberger C, Gerlich DW. Nat Rev Mol Cell Biol. 2011 Jul 13;12(8):469-82. PMID: 21750572

- Bourdeau A, Dube N, Tremblay ML. Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol. 2005 Apr;17(2):203-9. PMID: 15780598

- Bollen M, Beullens M. Signaling by protein phosphatases in the nucleus. Trends Cell Biol. 2002 Mar;12(3):138-45. PMID: 11859026