Humpath.com - Human pathology

Home > E. Pathology by systems > Endocrine system > Thyroid gland > thyroid Bethesda category 3

thyroid Bethesda category 3

Tuesday 23 August 2016

Thyroid FNAs that do not fit into benign, suspicious or malignant categories are included here.

AUS/FLUS is reserved for specimens that contain cells (follicular, lymphoid) with architectural atypia that isn’t sufficient to be classified as suspicious for a follicular neoplasm (FN) or malignancy and on the other hand atypia is more marked than benign change.

According to TBSRTC, AUS/FLUS is a category of resort and should not be used indiscriminately.

In a study, only 1.95% were of this category out of which some cases were papillary carcinoma and some were FA.

The cancer risk for this category according to TBSRTC is 5–15% and recommended management protocol is repeat FNA after sufficient time gap.

NB: The Bethesda System for Reporting Thyroid Cytology (TBSRTC)

See also

- thyroid FNA

Open references

- The Bethesda System for Reporting Thyroid Cytopathology: Interpretation and Guidelines in Surgical Treatment. Renuka IV et al., 2012. (Open access) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477437/

- Thyroid cytology—nuclear versus architectural atypia within the “Atypia of undetermined significance/follicular lesion of undetermined significance” Bethesda category have significantly different rates of malignancy. 2017. doi : 10.1002/cncy.21823