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thyroid Bethesda category 2

Tuesday 23 August 2016

This category includes benign follicular nodule (adenomatoid nodule, colloid nodule), lymphocytic (Hashimotos) thyroiditis and granulomatous (subacute) thyroiditis.

The benefit of thyroid FNA in these cases is when a reliably benign interpretation is done it avoids unnecessary surgery.

The term "benign follicular nodule" is applied to the most common benign pattern; where an adequate specimen is composed of varying proportion of colloid and benign follicular cells arranged as macro follicles and micro follicle fragments.

On histopathology, these nodules turned out to be nodules of multinodular goiter (MNG) or follicular adenomas (FAs).

In a study, the false negative rate was low (2%).

Other benign subcategories include “consistent with lymphocytic (Hashimotos) thyroiditis” in the proper clinical context and “consistent with granulomatous (subacute) thyroiditis”.

The criteria for Hashimotos thyroiditis is a polymorphic lymphoid population and occasional plasma cells and hurthle calls arranged in sheets or as isolated cells.

See also

- thyroid FNA

Open references

- The Bethesda System for Reporting Thyroid Cytopathology: Interpretation and Guidelines in Surgical Treatment. Renuka IV et al., 2012. (Open access) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477437/