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digestive neurofibroma

Friday 7 October 2016

The clinical significance of isolated, intestinal neurofibromas has not been well established.

Though typically benign lesions, they have been reported to undergo malignant transformation, particularly when associated with NF1 and in larger, plexiform lesions.

Gastrointestinal neurofibromas are usually asymptomatic, but may present with bleeding, anemia, or signs or symptoms of obstruction.

Indications for evaluation of gastrointestinal complications in the setting of NF1 include unexplained anemia, weight loss, gastrointestinal bleeding, abdominal pain, emesis, chronic diarrhea or signs of malabsorption.

NF1-associated isolated neurofibromas are rare entities and have an increased risk of malignant transformation when associated with NF1.

See also

- digestive polyp / digestive polyps
- neurofibroma

Open references

- An isolated neurofibromal polyp of the colon.
Hindy P, Parvin R, Hanna K, Andrawes S, Gress F, Goodman A.
Case Rep Gastroenterol. 2012 Jan;6(1):58-62. doi : 10.1159/000336214
PMID: 22423240 (Free)