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pancreatic mucinous non-neoplastic cyst

Sunday 16 October 2016

mucinous non-neoplastic cyst of the pancreas; MNNC

Although a mucinous nonneoplastic cyst (MNNC) of the pancreas is defined as a benign nonneoplastic lesion with no malignant potential, its histogenesis and etiology are still uncertain.

Although the genomic mutation rate detected in MNNC is relatively low, some results indicate that MNNCs may acquire genetic alteration similar to low-grade pancreatic intraepithelial neoplasia, furthering debate of the true nature of these lesions.

In one study, DNA mutations were demonstrated in 4 of 15 cases: 1 with KRAS mutation at codon 12 glycine (G) substitution by aspartic acid (D) (G12D), 1 with KRAS mutation at 12 glycine (G) substitution by arginine (R) (G12R), 1 with LOH at 10q (PTEN), and 1 with LOH at 17q (RNF43) (27246174).

Paywall References

- Molecular analysis of mucinous nonneoplastic cyst of the pancreas. Zhu B, Finkelstein SD, Feng G, Keswani RN, Lin X. Hum Pathol. 2016 Sep;55:159-63. doi : 10.1016/j.humpath.2016.05.009
PMID: 27246174