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acinar-to-ductal metaplasia

Wednesday 19 October 2016

acinar-to-ductal metaplasia lesion in pancreas; pancreatic acinar-to-ductal metaplasia

Molecular biology

- shortened telomeres are found in PanIN-associated acinar-to-ductal metaplasias, but not in isolated acinar-to-ductal metaplasia lesions.

  • These results indicate that isolated acinar-to-ductal metaplasias are not a precursor to PanIN.
  • They support the hypothesis that PanIN-associated acinar-to-ductal metaplasias arise secondary to PanIN lesions.

See also

- PanIns / PanIn

Open references

- Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.
Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Mod Pathol. 2011 Feb;24(2):256-66.
doi : 10.1038/modpathol.2010.181
PMID: 20871595