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MYB-NFIB-associated adenoid cystic carcinoma

Monday 31 October 2016

MYB/NFIB fusion gene associated adenoid cystic carcinoma

See also : MYB NFIB

Tumors:

- MYB-NFIB fusion gene in 60% of adenoid cystic carcinoma (ACC)

- MYB-NFIB fusion gene in mammary adenoid cystic carcinoma (MACC)

  • Adenoid cystic carcinoma of the breast is a rare histological type of triple-negative breast cancer with an indolent clinical behavior, often driven by the MYB-NFIB fusion gene.
  • The MYB-NFIB fusion gene was detected in both adenoid cystic carcinomas and their associated high-grade triple-negative breast cancer components.
  • Although the distinct components of both cases displayed similar patterns of gene copy number alterations, massively parallel sequencing analysis revealed intratumor genetic heterogeneity.
  • Adenoid cystic carcinomas of the breast with high-grade transformation are underpinned by the MYB-NFIB fusion gene and, akin to other forms of cancer, may be constituted by a mosaic of cancer cell clones at diagnosis.

Images

- mammary adenoid cystic carcinoma

See also

- adenoid cystic carcinoma