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cutaneous mammary-type secretory carcinoma

Tuesday 1 November 2016

Mammary-type secretory carcinoma of the skin; cutaneous MASC; Secretory Carcinoma of the Skin

Mammary analogue secretory carcinoma (MASC) is a low-grade salivary gland carcinoma that exhibits analogous features to secretory carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion.

Rare cases of purported secretory carcinoma of the skin adnexa have been reported.

Secretory carcinoma of the skin represents a phenotypic, immunohistochemical, and genetic counterpart to secretory carcinoma of the breast and salivary glands with ETV6 rearrangements.

Molecular biology

- ETV6 gene fusions / ETV6 rearrangements

  • ETV6-NTRK3 gene fusion

Paywall references

- Secretory Carcinoma of the Skin Harboring ETV6 Gene Fusions: A Cutaneous Analogue to Secretory Carcinomas of the Breast and Salivary Glands.
Bishop JA, Taube JM, Su A, Binder SW, Kazakov DV, Michal M, Westra WH.
Am J Surg Pathol. 2016 Sep 14.
PMID: 27631515