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ALK-negative inflammatory myofibroblastic tumor

Tuesday 1 November 2016

ALK-negative IMT

Inflammatory myofibroblastic tumor (IMT) is a genetically heterogenous tumor of the viscera and soft tissues, with multiple molecular features having been demonstrated in this tumor type.

About 50% of cases harbor an anaplastic lymphoma kinase (ALK) gene rearrangement.

Molecualr biology

- PDGFRB-ROS1 gene fusion
- ETV6-NTRK3 gene fusion

Paywall References

- ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors. Alassiri AH, Ali RH, Shen Y, Lum A, Strahlendorf C, Deyell R, Rassekh R, Sorensen PH, Laskin J, Marra M, Yip S, Lee CH, Ng TL. Am J Surg Pathol. 2016 Aug;40(8):1051-61. doi : 10.1097/PAS.0000000000000677
PMID: 27259007

See also

- inflammatory myofibroblastic tumor

- ETV6-NTRK3- associated tumors