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Afirma

Monday 14 November 2016

Afirma GEC; Afirma gene expression classifier

Afirma gene expression classifier / Afirma GEC

See also

- molecular pathology of thyroid FNA

Open references

- Afirma Benign Thyroid Nodules Show Similar Growth to Cytologically Benign Nodules During Follow-Up. Angell TE, Frates MC, Medici M, Liu X, Kwong N, Cibas ES, Kim MI, Marqusee E. J Clin Endocrinol Metab. 2015 Nov;100(11):E1477-83. doi : 10.1210/jc.2015-2658
PMID: 26353010 Free

- Wide Inter-institutional Variation in Performance of a Molecular Classifier for Indeterminate Thyroid Nodules. Marti JL, Avadhani V, Donatelli LA, Niyogi S, Wang B, Wong RJ, Shaha AR, Ghossein RA, Lin O, Morris LG, Ho AS. Ann Surg Oncol. 2015 Nov;22(12):3996-4001. doi : 10.1245/s10434-015-4486-3
PMID: 25862581 Free

- Use of the afirma┬« gene expression classifier for preoperative identification of benign thyroid nodules with indeterminate fine needle aspiration cytopathology.
Ali SZ, Fish SA, Lanman R, Randolph GW, Sosa JA.
PLoS Curr. 2013 Feb 11;5. pii: ecurrents.eogt.e557cbb5c7e4f66568ce582a373057e7. doi : 10.1371/currents.eogt.e557cbb5c7e4f66568ce582a373057e7
PMID: 23437421 Free

Paywall References

- Usage trends and performance characteristics of a "gene expression classifier" in the management of thyroid nodules: An institutional experience.
Samulski TD, LiVolsi VA, Wong LQ, Baloch Z.
Diagn Cytopathol. 2016 Nov;44(11):867-873. doi : 10.1002/dc.23559
PMID: 27534929

- UTILITY OF ULTRASOUND VERSUS GENE EXPRESSION CLASSIFIER IN THYROID NODULES WITH ATYPIA OF UNDETERMINED SIGNIFICANCE.
Villabona CV, Mohan V, Arce KM, Diacovo J, Aggarwal A, Betancourt J, Amer H, Jose T, DeSantis P, Cabral J.
Endocr Pract. 2016 Oct;22(10):1199-1203.
PMID: 27409819

- Impact of Afirma gene expression classifier on cytopathology diagnosis and rate of thyroidectomy.
Sacks WL, Bose S, Zumsteg ZS, Wong R, Shiao SL, Braunstein GD, Ho AS.
Cancer. 2016 Oct;124(10):722-728. doi : 10.1002/cncy.21749
PMID: 27347838

- Impact of the Afirma Gene Expression Classifier Result on the Surgical Management of Thyroid Nodules with Category III/IV Cytology and Its Correlation with Surgical Outcome.
Chaudhary S, Hou Y, Shen R, Hooda S, Li Z.
Acta Cytol. 2016;60(3):205-10. doi : 10.1159/000446797
PMID: 27344463

- Noninvasive Follicular Variant of Papillary Thyroid Carcinoma and the Afirma Gene-Expression Classifier.
Wong KS, Angell TE, Strickland KC, Alexander EK, Cibas ES, Krane JF, Barletta JA.
Thyroid. 2016 Jul;26(7):911-5. doi : 10.1089/thy.2015.0644
PMID: 27219469

- Impact of a gene expression classifier on the long-term management of patients with cytologically indeterminate thyroid nodules.
Singer J, Hanna JW, Visaria J, Gu T, McCoy M, Kloos RT.
Curr Med Res Opin. 2016 Jul;32(7):1225-32. doi : 10.1185/03007995.2016.1166103
PMID: 26973059

- LONG-TERM NONOPERATIVE RATE OF THYROID NODULES WITH BENIGN RESULTS ON THE AFIRMA GENE EXPRESSION CLASSIFIER.
Sipos JA, Blevins TC, Shea HC, Duick DS, Lakhian SK, Michael BE, Thomas MJ, Sosa JA.
Endocr Pract. 2016 Jun;22(6):666-72. doi : 10.4158/EP151006.OR
PMID: 26789352

- Gene expression classifier for the diagnosis of indeterminate thyroid nodules: a meta-analysis.
Santhanam P, Khthir R, Gress T, Elkadry A, Olajide O, Yaqub A, Driscoll H.
Med Oncol. 2016 Feb;33(2):14. doi : 10.1007/s12032-015-0727-3
PMID: 26749587

- Afirma GEC and thyroid lesions: An institutional experience.
Celik B, Whetsell CR, Nassar A.
Diagn Cytopathol. 2015 Dec;43(12):966-70. doi : 10.1002/dc.23378
PMID: 26466552

- Has Afirma gene expression classifier testing refined the indeterminate thyroid category in cytology?
Yang SE, Sullivan PS, Zhang J, Govind R, Levin MR, Rao JY, Moatamed NA.
Cancer Cytopathol. 2016 Feb;124(2):100-9. doi : 10.1002/cncy.21624
PMID: 26422098

- An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules.
McIver B, Castro MR, Morris JC, Bernet V, Smallridge R, Henry M, Kosok L, Reddi H.
J Clin Endocrinol Metab. 2014 Nov;99(11):4069-77. doi : 10.1210/jc.2013-3584
PMID: 24780044

- Surgical utility of Afirma: effects of high cancer prevalence and oncocytic cell types in patients with indeterminate thyroid cytology. Harrell RM, Bimston DN. Endocr Pract. 2014 Apr;20(4):364-9. doi : 10.4158/EP13330.OR PMID: 24246351

- Multicenter clinical experience with the Afirma gene expression classifier.
Alexander EK, Schorr M, Klopper J, Kim C, Sipos J, Nabhan F, Parker C, Steward DL, Mandel SJ, Haugen BR.
J Clin Endocrinol Metab. 2014 Jan;99(1):119-25. doi : 10.1210/jc.2013-2482
PMID: 24152684

- Does addition of BRAF V600E mutation testing modify sensitivity or specificity of the Afirma Gene Expression Classifier in cytologically indeterminate thyroid nodules?
Kloos RT, Reynolds JD, Walsh PS, Wilde JI, Tom EY, Pagan M, Barbacioru C, Chudova DI, Wong M, Friedman L, LiVolsi VA, Rosai J, Lanman RB, Kennedy GC.
J Clin Endocrinol Metab. 2013 Apr;98(4):E761-8. doi : 10.1210/jc.2012-3762
PMID: 23476074

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