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Russel body gastritis

Thursday 15 December 2016

Definition: Russel body gastritis is a variant of plasmocytic gastritis.

Images

- Russell body gastritis with many Mott cells. Mott cells are plasma cells packed with cytoplasmic immunoglobulin.

Russell body gastritis (RBG) is a very rare, well circumscribed lesion of plasma cells containing Russell bodies in the mucosa of the stomach.

Russell bodies are round, cytoplasmic, eosinophilic globules composed of immunoglobulins, not to be confused with Dutcher bodies, which are intranuclear inclusions in plasma cells (a plasma cell with Russell bodies is called a Mott cell).

Russell bodies are thought to arise from excess immunoglobulins due to dysfunctional secretion (Arch Pathol Lab Med 2004;128:915). As seen in this case, extracellular Russell bodies can be present in the stroma (Hum Pathol 2010;41:134).

Case records

- http://www.pathologyoutlines.com/caseofweek/case410.htm