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lymphomatoid papulosis type D

Friday 6 January 2017

Type D lymphomatoid papulosis

Definition: Three histological subtypes of lymphomatoid papulosis (LyP), type A (histiocytic), type B (mycosis fungoides like) and type C (anaplastic large cell lymphoma like) are well recognized. Two new histological variants, type D (simulating an aggressive epidermotropic cytotoxic lymphoma) and type E (angioinvasive type) has been also described.

Authors emphasize the indolent course of this entity although the histology would suggest a more aggressive disease.


- atypical dermal lymphoid infiltrate with epidermotropism
- immunohistochemical markers show a diffuse positivity for CD3 , CD8 , CD56 , T1A and granzyme B with the focal positivity of CD30.

Open references

- Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma.
Mani V, George R, Vijayakumar K, Nair S.
Indian J Pathol Microbiol. 2016 Jan-Mar;59(1):81-3. doi : 10.4103/0377-4929.174823
PMID: 26960644 Free

- Lymphomatoid papulosis type D or an aggressive epidermotropic CD8(+) cytotoxic T-cell lymphoma?
Andersen RM, Larsen MS, Poulsen TS, Lauritzen AF, Skov L.
Acta Derm Venereol. 2014 Jul;94(4):474-5. doi : 10.2340/00015555-1750
PMID: 24217891 Free

- Lymphomatoid papulosis type D in a Chinese young man: a newly recognized variant.
Wen PF, Jia L, Zhang M, Li GD, Liu WP, Wang L.
Chin Med J (Engl). 2013 Oct;126(20):3997-8.
PMID: 24157177