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compensatory hyperplasia

Monday 9 January 2017

  • The source of growth factors in compensatory hyperplasia and the stimuli for the production of these growth factors are less well defined. The increase in tissue mass after some types of cell loss is achieved not only by proliferation of the remaining cells but also by the development of new cells from stem cells.
  • For instance, in the liver, intrahepatic stem cells do not play a major role in the hyperplasia that occurs after hepatectomy but they may participate in regeneration after certain forms of liver injury, such as chronic hepatitis, in which the proliferative capacity of hepatocytes is compromised.
  • Recent data from clinical observations and experimental studies have demonstrated that the bone marrow contains stem cells that may be able to give rise to many types of differentiated, specialized cell types, including some liver cells.