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quadruple wild type GIST

Friday 13 January 2017

quadruple-WT GIST

Molecular biology

- MEN1 mutations
- MAX mutations
- FGFR1 alterations ( 27974047 )
- NTRK3 alterations ( 27974047 )

Paywall references

- Genome-wide Analyses Identifies MEN1 and MAX Mutations and a Neuroendocrine-like Molecular Heterogeneity in Quadruple WT GIST.
Pantaleo MA, Urbini M, Indio V, Ravegnini G, Nannini M, De Luca M, Tarantino G, Angelini S, Gronchi A, Vincenzi B, Grignani G, Colombo C, Fumagalli E, Gatto L, Saponara M, Ianni M, Paterini P, Santini D, Pirini MG, Ceccarelli C, Altimari A, Gruppioni E, Renne SL, Collini P, Stacchiotti S, Brandi G, Casali PG, Pinna AD, Astolfi A, Biasco G.
Mol Cancer Res. 2017 Jan 27. doi : 10.1158/1541-7786.MCR-16-0376
PMID: 28130400

Open references

- FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.
Shi E, Chmielecki J, Tang CM, Wang K, Heinrich MC, Kang G, Corless CL, Hong D, Fero KE, Murphy JD, Fanta PT, Ali SM, De Siena M, Burgoyne AM, Movva S, Madlensky L, Heestand GM, Trent JC, Kurzrock R, Morosini D, Ross JS, Harismendy O, Sicklick JK.
J Transl Med. 2016 Dec 14;14(1):339.
PMID: 27974047 Free

- Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).
Nannini M, Astolfi A, Urbini M, Indio V, Santini D, Heinrich MC, Corless CL, Ceccarelli C, Saponara M, Mandrioli A, Lolli C, Ercolani G, Brandi G, Biasco G, Pantaleo MA.
BMC Cancer. 2014 Sep 20;14:685. doi : 10.1186/1471-2407-14-685
PMID: 25239601

- Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). Nannini M, Astolfi A, Urbini M, Indio V, Santini D, Heinrich MC, Corless CL, Ceccarelli C, Saponara M, Mandrioli A, Lolli C, Ercolani G, Brandi G, Biasco G, Pantaleo MA. BMC Cancer. 2014 Sep 20;14:685. doi : 10.1186/1471-2407-14-685
PMID: 25239601 Free

- Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways. Pantaleo MA, Nannini M, Corless CL, Heinrich MC. Cancer Med. 2015 Jan;4(1):101-3. doi : 10.1002/cam4.325
PMID: 25165019 Free