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Kaposi sarcoma

Friday 12 December 2003

Definition: Kaposi sarcoma is a multifocal HHV-8-driven vascular proliferation which does not show conventional features of malignancy—in particular, it may regress spontaneously.


- Kaposi sarcoma

- polypoid lesion : pyogenic granuloma-like Kaposi sarcoma (H&E, HHV-8).

- micronodular growth in Kaposi sarcoma

- promontory sign in Kaposi sarcoma

- anaplastic Kaposi sarcoma - palate. (HHV-8 nuclear signaling)


- spindle cells forming slit-like vascular spaces.
- extravasated red blood cells and hemosiderin deposition.
- IHC : HHV8 IHC+ (nuclear speckles)

Digital cases

- HPC:28 : Kaposi sarcoma
- UI:488 - cutaneous Kaposi sarcoma.
- JRC:10989 : Kaposi sarcoma.
- JRC:11011 : Kaposi sarcoma.
- Kaposi sarcoma of skin of the skin on Flick by ddkri

It shows relative sparing of certain tissues such as brain, kidney and skeletal muscle, is most often diploid, is very difficult to transplant/xenograft and does not appear to show any conventional pattern of metastasis.


- Human herpesvirus-8 (HHV-8) infection is considered the initiating factor in all forms of Kaposi sarcoma (KS)


- No consistent abnormality

See also

- Tumors


- Verschuren EW, Jones N, Evan GI. The cell cycle and how it is steered by Kaposi’s sarcoma-associated herpesvirus cyclin. J Gen Virol. 2004 Jun;85(Pt 6):1347-61. PMID: 15166416