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Home > E. Pathology by systems > Reproductive system > Female genital system > Uterus > Uterine cervix > microglandular hyperplasia

microglandular hyperplasia

Thursday 11 May 2017

cervical microglandular hyperplasia

Cervical microglandular hyperplasia shows non neoplastic back-to-back glands with a neutrophilic infiltrate, accompanied by squamous metaplasia.

A major clue to the diagnosis of microglandular hyperplasia is the neutrophils within the non-neoplastic glands.

Microglandular hyperplasia shows benign back to back glands with intraluminal neutrophils.

Differential diagnosis

- invasive endometrial carcinoma

  • Invasive endometrial carcinoma shows malignant infiltrative glands with a desmoplastic response.
  • It is differentiated from endocervical adenocarcinoma on IHC by positivity for vimentin and more frequent positivity for ER and PR.perplasia