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focal active colitis

Thursday 18 December 2003

This inflammatory pattern is associated with bacterial (Campylobacter, Salmonella, Shigella, E. cati, Yersinia) and viral infections or drug-induced injury.

Other clinical associations include irritable bowel syndrome and inflammatory bowel disease, particularly Crohn’s disease.

In the absence clinical colitis, these changes often remain unexplained and could be related to bowel preparation.

Synopsis

- neutrophilic cryptitis : focal neutrophilic infiltrates in crypt epithelium

- scant neutrophilic infiltrates in lamina propria

  • Neutrophils within lamina propria absent or scant

- no crypt architectural distortion
- no Paneth cell metaplasia

Etiology

- Crohn disease (10%-17%)
- acute infectious-type colitis (27% to 50%)

  • Campylobacter sp. , Salmonella sp. , Shigella sp. , Eschericcia coli, Yersinia sp.

- viral colonic infections / viral colitis
- drug-associated colitis / drug-induced injury of colonic mucosa
- allergic colitis
- ulcerative colitis
- Hirschsprung disease
- irritable bowel syndrome
- idiopathic focal active colitis (27%)

This pattern of injury is associates with bacterial (Campylobacter, Salmonella, Shigella, E. coli, Yersinia) and viral infections or drug-induced injury. Other clinical associations include irritable bowel syndrome and inflammatory bowel disease, particularly Crohn’s disease.

In the absence of colitic signs or symptoms, however, these changes often remain unexplained and may reflect bowel preparations.

Cases

- http://www.pathobin.com/cases/case/262/#

See also

- focal active gastritis

References

- Xin W, Brown PI, Greenson JK. The clinical significance of focal active colitis in pediatric patients. Am J Surg Pathol. 2003 Aug;27(8):1134-8. PMID: 12883246

- Wightman HR. Active focal colitis. Hum Pathol. 1998 Aug;29(8):887-8. PMID: 9712435

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