- Human pathology

Home > F. Pathology by regions > Head and neck > Head > Face > nasolabial duct cyst

nasolabial duct cyst

Thursday 4 January 2018

Nasolabial cyst ; Klestadt cyst ; Nasal alveolar cyst
; Nasoalveolar cyst
; Nasal wing cyst
; Nasal vestibule cyst
; Mucoid cyst of the noseh


Definition : Nasolabial duct cysts are relatively uncommon benign extraosseous maxillary lesions.

Nasolabial cyst lining epithelium is characteristically composed of a basal layer of cuboidal cells and a luminal layer of columnar secretory cells with interspersed mucous goblet cells. In addition, areas of multilayered epithelium and squamous metaplasia may be seen.

The cyst stroma is characterized by collagen-rich fibrovascular tissue with variably admixed chronic inflammatory cells.

Basal layer cells express p63 and cytokeratin 5/6, while goblet cells express MUC-2 and MUC-5AC mucins, supporting the notion that nasolabial cysts can be understood as hamartomatous, locally expansile remnants of distal nasolacrimal duct development.

Differential diagnosis

- cyst of the incisive papilla
- cystic salivary gland tumors
- dilated salivary duct due to obstruction
- epidermal inclusion cyst
- glandular odontogenic cyst
- hidrocystoma
- nasopalatine duct cyst


- The nasolabial cyst: a nonodontogenic oral cyst related to nasolacrimal duct epithelium. Toribio Y, Roehrl MH. Arch Pathol Lab Med. 2011 Nov;135(11):1499-503. doi : 10.5858/arpa.2010-0338-RS PMID: 22032581