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intraductal tubulopapillary neoplasm

Wednesday 28 March 2018

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas

Definition: Intraductal tubulopapillary neoplasm (ITPN) is a relatively recently described member of the pancreatic intraductal neoplasm family.

ITPN is a distinct clinicopathologic entity in the pancreas. Despite the difficulties of determining the extent of invasive carcinoma in many cases, the overall outcome seems to be relatively favorable and substantially better than that of conventional pancreatic ductal adenocarcinoma, even when only the cases with invasive carcinoma are considered.


- intraductal tubulopapillary neoplasm (ITPNs)


- Tubular pattern
- cuboidal cells with minimal eosinophilic cytoplasm lacking apparent mucin
- frequent mitoses
- MUC1 & MUC6 (+), MUC5AC (-).

Open references


- Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases. Basturk O, Adsay V, Askan G, Dhall D, Zamboni G, Shimizu M, Cymes K, Carneiro F, Balci S, Sigel C, Reid MD, Esposito I, Baldaia H, Allen P, Klöppel G, Klimstra DS. Am J Surg Pathol. 2017 Mar;41(3):313-325. doi : 10.1097/PAS.0000000000000782 PMID: 27984235 Free