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siderotic regenerative nodule

Tuesday 6 November 2018

Definition : Large regenerative nodules in cirrhotic livers may accumulate iron and develop internal iron-poor foci of hyperplasia or malignancy.

The nodule-within-nodule sign, which reflects the unique histopathology of hepatocellular carcinoma in large siderotic regenerative nodules, is strongly suggestive of early hepatocellular carcinoma, even if serologic markers and biopsy results do not support this diagnosis.

See also

- siderotic nodule

Paywall references

- Hepatocellular carcinoma within siderotic regenerative nodules: appearance as a nodule within a nodule on MR images. Mitchell DG, Rubin R, Siegelman ES, Burk DL Jr, Rifkin MD. Radiology. 1991 Jan;178(1):101-3. PMID: 1845784

- Iron-negative foci in siderotic macroregenerative nodules in human cirrhotic liver. A marker of incipient neoplastic lesions. Terada T, Nakanuma Y. Arch Pathol Lab Med. 1989 Aug;113(8):916-20. PMID: 2757493