- Human pathology

Home > F. Pathology by regions > Head and neck > Neck > p16+ branchial cleft cyst

p16+ branchial cleft cyst

Saturday 28 September 2019

p16–can be positive in benign entities like branchial cleft cyst. But p16INK4a is not a reliable surrogate marker for HPV infection in branchial cleft cysts.

Nota bene : High-risk human papillomavirus (HPV) DNA has been reported to be present in branchial cleft cysts, but further information is required to clarify the role of HPV infection in branchial cleft cysts. (30008839) Infection with high-risk HPV types can be observed in branchial cleft cysts.

Differential diagnosis

- metastasis of p16+ SCC

See also

- branchial cleft cyst

  • p16- branchial cleft cyst

Open references

- p16(INK4A) immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx. Pai RK, Erickson J, Pourmand N, Kong CS. Cancer. 2009 Apr 25;117(2):108-19. doi : 10.1002/cncy.20001 PMID: 19365840

Paywall refererences

- Case report of a p16INK4A-positive branchial cleft cyst. McLean T, Iseli C, Amott D, Taylor M. J Laryngol Otol. 2015 Jun;129(6):611-3. doi : 10.1017/S0022215114003223 PMID: 26004639