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complete hydatiform mole

Monday 15 July 2019

complete mole


- complete hydatiform mole


- large villi distended with abundant stromal fluid and formation of a cistern.
- Strands of fibrillar material are seen within and around the cistern.
- Trophoblastic proliferation is seen.
- nodular trophoblastic hyperplasia (seen as eosinophilic nests and clusters).
- Haphazard circumferential proliferation of cytotrophoblast and syncytiotrophoblast around individual villi in this image.
- Some of the nuclei show considerable atypia.
- club-shaped villi in a complete mole.

Between 5% to 15% of patients with complete moles may develop persistent gestational trophoblastic neoplasia requiring chemotherapy.

Serial determinations of serum hCG levels are helpful in optimizing treatment.

See also

- partial hydatiform mole