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endometrial intraepithelial carcinoma

Wednesday 18 March 2020

Definition : Endometrial intraepithelial carcinoma (EIC) is a recently described lesion characterized by replacement of endometrial surface epithelium or glands by malignant cells resembling high-grade invasive endometrial carcinoma.

EIC has been identified in a high proportion of uteri containing serous carcinoma, but its association with other endometrial tumors is unknown.

EIC is frequently and specifically associated with uterine tumors displaying serous differentiation.

The findings suggest that EIC represents a form of intraepithelial tumor growth characteristic of serous carcinoma and serous MMMT and that EIC is the likely precursor of these neoplasms.

Findings provide further evidence supporting the view that MMMTs represent variants of carcinoma not sarcoma.

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See also

- serous endometrial intraepithelial carcinoma