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hidradenoma papilliferum

Friday 28 August 2020


Definition : An hidradenoma papilliferum is a rare benign tumor of apocrine glands ( apocrine tumors ) . It usually presents as an asymptomatic flesh-colored nodule in the anogenital area of women.

Hidradenoma papilliferum is an uncommon benign neoplasm arising from apocrine glands, seen in middle-aged females, commonly between the ages of 30-49 years.

It usually presents as a firm, flesh to red-colored nodule in the anogenital area.

Rarely, it can be seen over the head and neck, and over modified apocrine gland areas such as breast, external ear canal, and eyelid. It is then referred to as ectopic hidradenoma papilliferum.

Histopathology shows a partly solid or solid-cystic dermal lesion with anastomosing papillary structures and tubules as well as some glandular areas. The epithelial lining consists of an inner layer of columnar cells with decapitation secretion in the lumen and frequently an outer myoepithelial layer. The tumor has got a good prognosis and malignant transformation is extremely rare.


- dermal tumor
- papillary folds , tubules, cystically dilated spaces
- lumen lined by columnar cells with decapitation secretion


- vulvar hidradenoma papilliferum
- perianal hidradenoma papilliferum

Differential diagnosis

- syringocystadenoma papilliferum

  • Frequently connects to epidermis
  • Associated with characteristic plasma cell infiltrate
  • More common on head and neck

- Hidradenocarcinoma papilliferum

  • Asymmetric, infiltrative growth pattern, cytologic atypia, cribriform structures

- tubular apocrine adenoma

  • Predominantly tubular structures
  • Less complex architecture

- papillary eccrine adenoma
- eccrine differentiation

Open references


Paywall references

- Daniel F, Mahmoudi A, de Parades V, Flejou JF, Atienza P. An uncommon perianal nodule: Hidradenoma papilliferum. Gastroenterol Clin Biol. 2007;31:166–8.

- Vang R, Cohen PR. Ectopic hidradenoma papilliferum: A case report and review of literature. J Am Acad Dermatol. 1999;41:115–8.

- Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV. Hidradenoma papilliferum with a ductal carcinoma in situ component: Case report and review of literature. Am J Dermatopathol. 2008;30:392–4.