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inflammatory fibroid polyp

Friday 27 February 2004

Inflammatory Fibroid Polyps of the Gastrointestinal Tract

WP

Definition: Inflammatory fibroid polyps (IFPs) are rare mesenchymal tumors of the gastrointestinal tract that consist of spindle-shaped stromal cells and an inflammatory infiltrate rich in eosinophils. Their etiology and histogenesis remain unknown.

Inflammatory fibroid polyp, abbreviated IFP, is a benign abnormal growth of tissue projecting into the lumen of the gastrointestinal tract. The endoscopic differential diagnosis includes other benign, pre-malignant and malignant gastrointestinal polyps.

Microscopy

IFPs consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially eosinophils.They may have leiomyoma/schwannoma-like areas with nuclear palisading.

Immunochemistry

They typically stain with CD34 and vimentin, and, generally, do not stain with CD117 and S100.

- CD34+ (14707872)
- fascin+ (14707872)
- cyclin-D1+ (14707872)

References

- Inflammatory Fibroid Polyps of the Gastrointestinal Tract: Spectrum of Clinical, Morphologic, and Immunohistochemistry Features. Liu TC, Lin MT, Montgomery EA, Singhi AD. Am J Surg Pathol. 2013 Feb 15. PMID: 23426127

- Pantanowitz L, Antonioli DA, Pinkus GS, Shahsafaei A, Odze RD. Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin. Am J Surg Pathol. 2004 Jan;28(1):107-14. PMID: 14707872