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vesiculobullous and acantholytic reaction pattern

Thursday 11 February 2021

vesiculobullous and acantholytic reaction patterns

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Anomalies

- spongiosis: accumulation of extracellular fluid within epidermis with resultant separation of keratinocytes

  • eczematous dermatitis
  • allergic contact dermatitis
  • miliaria

- acantholysis: loss of appropriate keratinocyte cell-cell contact

- reticular degeneration: ballooning degeneration with secondary rupture and death of the keratinocytes

- cytolysis : disruption of keratinocytes due to friction or heat

- basement membrane zone disruption or destruction from primary structural deficiencies, humoral and cellular immunologic damage

See also

- cutaneous lesional patterns