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villitis of unknown etiology

Sunday 23 January 2022



Villitis of unknown etiology (VUE) (also known as chronic villitis) is a placental injury. VUE is an inflammatory condition involving the chorionic villi (placental villi).

VUE is a recurrent condition and can be associated with intrauterine growth restriction (IUGR). IUGR involves the poor growth of the foetus, stillbirth, miscarriage, and premature delivery. VUE recurs in about 1/3 of subsequent pregnancies.

VUE is a common lesion characterised by inflammation in the placental chorionic villi. VUE is also characterised by the transfer of maternal lymphocytes across the placenta.

VUE is diagnosed in 7–10% placentas in pregnancies. Roughly 80% of the VUE cases are in term placentas (greater than 37 weeks of pregnancy).

A case of VUE in a placenta less than 32 weeks old should be screened for infectious villitis.