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nodal infectious mononucleosis

Monday 24 October 2022

Lymph node lesions in infectious mononucleosis (IM) show a marked histological diversity and may occasionally be confused with malignant lymphoma.

The lymph node lesion of infectious mononucleosis (IM) shows marked histologic diversity and occasionally may be confused with malignant lymphoma.


- geographic nodal necrosis / geographic lymph node necrosis

  • The necrotic area can comprised 50% or more of a cervical lymph node.

- angiocentric lymphoproliferative lesions

- numerous centroblasts

  • The large lymphoid cells, including RS-like cells, are CD3-, CD5-, CD15-, CD20+, CD30+, CD45RO-, CD79a+, LMPI+, and EBNA2+.

- immunoblasts
- Reed-Sternberg (RS)-like cells

- In situ hybridization study discloses that large cells are associated with Epstein-Barr virus (EBV).