Humpath.com - Human pathology

Home > E. Pathology by systems > dermal mucinoses

dermal mucinoses

Friday 20 January 2023

Dermal mucinose ; dermal mucinosis

Definition : Dermal mucin increase.

Increased dermal mucin is a feature of lupus erythematosus (LE), but is not specifical. 25925107

Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans. (19614999)

Normal photodamaged skin showed significantly more mucin in the superficial reticular dermis compared to non-photodamaged skin. 25925107

While LE is associated with increased mucin deposition, scant to moderate amount of mucin alone has limited specificity and is common in other dermatitides or photodamaged skin.25925107

Etiology

- secondary mucinosis are :

- localized cutaneous mucinosis

  • venous insufficiency

Open references

- Specificity of dermal mucin in the diagnosis of lupus erythematosus: comparison with other dermatitides and normal skin. 2015. PMID: 25925107
https://pubmed.ncbi.nlm.nih.gov/25925107/

Paywall references

- https://pubmed.ncbi.nlm.nih.gov/19614999/