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dermal mucinoses
Friday 20 January 2023
Dermal mucinose ; dermal mucinosis
Definition : Dermal mucin increase.
Increased dermal mucin is a feature of lupus erythematosus (LE), but is not specifical. 25925107
Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans. (19614999)
Normal photodamaged skin showed significantly more mucin in the superficial reticular dermis compared to non-photodamaged skin. 25925107
While LE is associated with increased mucin deposition, scant to moderate amount of mucin alone has limited specificity and is common in other dermatitides or photodamaged skin.25925107
Etiology
secondary mucinosis are :
- thyroid dysfunction
- lupus erythematosus
- dermatomyositis
- scleroderma
- granuloma annulare
- graft-vs-host disease ( GVH Disease ) signe
- mucin deposition post-ultraviolet
- mucin deposition photochemotherapy treatment
localized cutaneous mucinosis
- venous insufficiency
Open references
Specificity of dermal mucin in the diagnosis of lupus erythematosus: comparison with other dermatitides and normal skin. 2015. PMID: 25925107
https://pubmed.ncbi.nlm.nih.gov/25925107/
Paywall references
