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sclerosing pneumocytoma

Saturday 6 March 2004

sclerosing hemangioma of the lung; pulmonary sclerosing hemangioma; Renamed as "sclerosing pneumocytoma"


Definition: Sclerosing hemangioma (SH) is an uncommon pulmonary tumor thought to derive from primitive respiratory epithelium consisting of 2 cell populations (cuboidal surface and polygonal stromal cells) and sharing some clinical characteristics (frequent occurrence in nonsmoking women of Asian ethnicity) with bronchioloalveolar carcinoma with which it has been suggested a possible common origin.


- Sclerosing pneumocytoma

Digital slides

- JRC:19394 : Sclerosing hemangioma of the lung.
- JRC:19432 : Sclerosing hemangioma of the lung.


- endobronchial polyp with bronchial obstruction (14704717)
- four architectural patterns

- round cells coexpressing thyroid transcription factor-1 and epithelial membrane antigen without cytokeratin immunoreactivity


- TTF-1+ (thyroid transcription factor-1)
- EMA+
- CK-


- familial adenomatous polyposis (15188145)

Molecular biology

- EGFR expression
- p16 locus LOH (17895751)
- RB locus LOH (17895751)


- Sclerosing Hemangioma of the Lung. CPT Joren B. Keylock, MC, USA; Jeffrey R. Galvin, MD; Teri J. Franks, MD. Archives of Pathology and Laboratory Medicine: Vol. 133, No. 5, pp. 820–825. (Free access)


- Sartori G, Bettelli S, Schirosi L, Bigiani N, Maiorana A, Cavazza A, Rossi G. Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung. Am J Surg Pathol. 2007 Oct;31(10):1512-1520. PMID: 17895751