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liver allograft rejection

Monday 15 March 2004

Liver allograft rejection is mediated by the immune response of the recipient to allogeneic antigens expressed by the donor liver. Multiple immunologic mechanisms participate in the alloimmune reaction.

Clinically, there are three types of rejection:
- hyperacute liver allograft rejection (humoral rejection), relatively uncommon.
- acute liver allograft rejection (cellular liver allograft rejection), commonly occurring during the first few months after transplantation.
- chronic liver allograft rejection (ductopenic liver allograft rejection), a manifestation of bile duct loss.

Types

- hyperacute liver allograft rejection (humoral rejection)

- acute liver allograft rejection (acute liver allograft rejection)

  • portal acute rejection
  • centrilobular acute rejection
    • allograft associated veno-occlusive disease

- chronic liver allograft rejection

  • ductopenic chronic hepatic allograft rejection
  • hepatocytary chronic hepatic allograft rejection (post-allograft ’autoimmune hepatitis’)