Humpath.com - Human pathology

Home > E. Pathology by systems > Endocrine system > Adrenals > adrenal cortical adenoma

adrenal cortical adenoma

Tuesday 16 March 2004

adrenal cortical adenomas; adrenocortical adenoma

Definition: Adrenocortical adenomas are a functionally heterogeneous group of benign neoplasms that can differentiate toward any of the cortical layers.

Images

- Nuclear pseudoinclusions in adrenal cortical adenoma

- Adrenal cortical adenoma

Digital cases

- JRC:14604 : Adrenal cortical adenoma.
- JRC:14612 : Atypical adrenal cortical adenoma.
- JRC:18772 : Adrenal cortical adenoma.
- JRC:18775 : Adrenal cortical adenoma, left, with Cushing’s syndrome (F 43 y/o).
- JRC:18766 : Adenoma, adrenal cortex; secreting aldosterone (F, 46 y/o)

These tumors can be associated with the overproduction of glucocorticoids (Cushing syndrome), androgenic or estrogenic steroids (adrenogenital syndromes), or mineralocorticoids (Conn syndrome).

Mixed syndromes can develop, and cortical adenomas without apparent functional activity are relatively common.

Types

- Cushing syndrome-associated adrenocortical adenoma
- aldosterone-producing adrenocortical adenoma
- virilizing adrenocortical adenoma

Predisposition

- Carney triad (MIM.604287) (23681078)

See also

- adrenocortical tumors
- Conn syndrome

References

- Adrenal Cortical Adenoma: The Fourth Component of the Carney Triad and an Association With Subclinical Cushing Syndrome. Carney JA, Stratakis CA, Young WF Jr. Am J Surg Pathol. 2013 May 15. PMID: 23681078

- Wieneke JA, Thompson LD, Heffess CS. Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol. 2003 Jul;27(7):867-81. PMID: 12826878