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EBV-associated diseases

Tuesday 6 April 2004

Digital case

- HPC:193 : EBV-associated infectious mononucleosis
- HPC:308 : EBV-associated infectious mononucleosis (Bilateral tonsillar hypertrophy)
- HPC:316 : EBV-associated nasal T/NK lymphoma
- HPC:320 : Undifferentiated carcinoma of the nasopharynx (Epstein-Barr virus associated)
- HPC:333 : EBV-associated infectious mononucleosis (Lymph node)


- non-tumoral diseases

- EBV-associated tumors

  • in immunocompromised host
    • B cell malignancies
    • EBV-associated smooth muscle cell tumors
  • immunocompetent host
    • B cell malignancies
      • Burkitt lymphoma
      • classic Hdgkin lymphoma
    • T cell malignancies
      • extranodal NK/T cell lymphoma, nasal type
      • EBV-associated hemophagocytic syndrome T cell lymphoma
    • epithelial cell malignacies
      • EBV-associated undifferentiated carcinoma (EBV-associated undifferenciated carcinoma of nasopharyngeal type, UCNT)
      • lymphoepithelioma-like carcinoma (salivary, thymus, lungs, stomach)
      • EBV-associated mammary carcinoma (breast carcinoma)
      • EBV-associated hepatocellualr carcinoma
    • mesenchymal malignancies
      • EBV-associated follicular dendritic cell sarcoma


- Kutok JL, Wang F. Spectrum of Epstein-Barr Virus-associated diseases. Annu Rev Pathol 1:375-404, 2006

- Hammerschmidt W, Sugden B. Epstein-Barr virus sustains Burkitt’s lymphomas and Hodgkin’s disease. Trends Mol Med. 2004 Jul;10(7):331-6. PMID: 15242681

- Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med. 2004 Mar 25;350(13):1328-37. PMID: 15044644

- Khanna R, Tellam J, Duraiswamy J, Cooper L. Immunotherapeutic strategies for EBV-associated malignancies. Trends Mol Med. 2001 Jun;7(6):270-6. PMID: 11378517

- Gulley ML. Molecular diagnosis of Epstein-Barr virus-related diseases. J Mol Diagn. 2001 Feb;3(1):1-10. PMID: 11227065