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occlusion of main hepatic veins

Tuesday 13 April 2004

Etiology

- primary
- secondary

  • ulcerative colitis
  • drugs (oral contraceptives)
  • neoplasms.

Synopsis

Early stages

- marked dilatation in the center of the central vein
- marked dilatation of pericentral sinusoids

  • dilated sinusoids contain lysed erythrocytes

- perivenular fibrosis
- periportal regeneration with nodular changes

Late stages

- fibrosis and cirrhosis similar to liver in chronic cardiac failure

Differential diagnosis

- passive congestion (cardiac failure)