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cyclic neutropenia

Tuesday 13 April 2004

Etiology

- Mutations in ELA2, the gene encoding neutrophil elastase (NE)(also causes severe congenital neutropenia)

Complications

- Enteritis necroticans with recurrent enterocutaneous fistulae caused by Clostridium perfringens (14734887)

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References

- Horwitz M, Benson KF, Duan Z, Li FQ, Person RE. Hereditary neutropenia: dogs explain human neutrophil elastase mutations. Trends Mol Med. 2004 Apr;10(4):163-70. PMID: 15059607