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Wednesday 14 April 2004


Definition : Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin that surfaced in the early 2000s caused by the first-identified strain of the SARS coronavirus (SARS-CoV or SARS-CoV-1).

In late 2017, Chinese scientists traced the virus through the intermediary of civets to cave-dwelling horseshoe bats in Yunnan province. No cases of the first SARS-CoV have been reported worldwide since 2004.

In 2019, a related virus strain, SARS-CoV-2, was discovered. This new strain causes COVID-19, a disease which brought about the ongoing 2019–20 coronavirus disease and coronavirus pneumonia pandemic.


- exudative phase of acute lung injury

  • proliferative phase of acute lung injury
  • edema
  • inflammatory infiltrate
  • pneumocyte hyperplasia
  • fibrinous exudates
  • organization

- diffuse alveolar damage pattern of acute lung injury
- acute fibrinous organizing pneumonia pattern (AFOP pattern)
- squamous metaplasia
- scattered multinucleate giant cells
- vascular fibrin thrombi
- pulmonary infarcts
- vascular endothelial damage of both small- and mid-sized pulmonary vessels


- invasive fungal disease

  • Aspergillosis

- cytomegalovirus infection


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