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p14(ARF)

MIM.600160 9p21

Wednesday 21 April 2004

CDKN2A locus gives rise to 2 distinct transcripts from different promoters.

The transcripts have been designated p16(INK4A) and p14(ARF). Each has a 5-prime exon which is spliced into common exons 2 and 3.

p14ARF increases p53 levels by inhibiting MDM2 activity.

Pathology

- p14ARF is frequently and differentially methylated in ependymal tumours. (14636164)

See also

- P14(ARF)-HDM2-P53 pathway

References

- Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006 Sep;7(9):667-77. PMID: 16921403

- Costa RH, Kalinichenko VV, Major ML, Raychaudhuri P. New and unexpected: forkhead meets ARF. Curr Opin Genet Dev. 2005 Feb;15(1):42-8. PMID: 15661532

- Burd CG, Strochlic TI, Gangi Setty SR. Arf-like GTPases: not so Arf-like after all. Trends Cell Biol. 2004 Dec;14(12):687-94. PMID: 15564045