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Tuesday 1 June 2004


Definition: Acantholysis is a disruption of the epidermal squamous epithelium. The desmosomal connections between the epithelial cells are destroyed. As a result the cells separate and become round.
It is a lack of cell adhesion).


- acantholytic keratinocytes

Etiology : some examples of acantholytic anomalies

- Darier’s disease ; acantholytic dyskeratosis / acantholysis

- In grover disease / Transient acantholytic dermatosis

- acanthotic squamous cell carcinoma

- pemphigus
- cutaneous viral infections

  • HSV infections / herpes simplex infections (HSV1 and HSV2)
  • varicella zoster infection / zona / herpes zoster infection


- Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease. Br J Dermatol. 2004 May;150(5):821-8. PMID: 15149492