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cutaneous melanocytic tumors

Thursday 1 July 2004

Digital cases

- UI:1831 - dermal melanocytic nevus

1. BASAL MELANOCYTE PROLIFERATION:

- lentigo simplex
- solar lentigo
- melanotic macule (labial and genital)
- PUVA lentigo
- lentiginous nevus

2. MELANOCYTIC NEVI:

- common nevus (junctional, compound, intradermal)
- Meyerson nevus
- congenital nevus
- combined nevus
- inverted nevus
- recurrent nevus
- Halo nevus
- Spitz nevus (spindle and epithelioid cell nevus)
- pigmented spindle cell nevus (Reed nevus)
- deep-penetrating nevus (plexiform spindle cell nevus)

3. DERMAL MELANOCYTIC LESIONS (MELANOCYTOMAS):

- mongolian spot
- nevus of Ota, nevus of Ito
- blue nevus, cellular blue nevus
- dermal melanocyte hamartoma
- cutaneous neurocristic hamartoma

4. ATYPICAL MELANOCYTIC LESIONS:

- dysplastic nevus (atypical nevus)

5. MALIGNANT MELANOCYTIC LESIONS:

- malignant melanoma

  • lentigo maligna

- squamo-melanocytic tumor

Diagnosis : Description / Items

- periphery / circumscription
- cellularity
- extension in subcutis
- cell shape : fusiform cells / round cells
- margins : pushing margins
- fasciculation
- neural structures
- cellular atypia
- junctional activity
- epidermal invasion
- peripheral inflammation
- necrosis
- mitoses / mitotic figures
- intracranial extension for scalp lesions
- stromal changes

  • cilated vessels
  • pseudoangiomatous features
  • hyaline angiopathy
  • myxoid changes
  • - sclerosis
  • hyalinization of stroma
  • interstitial edema

- amelanotic changes
- ballon cell change

Diagnosis : Appearnce

See also

- cutaneous tumors
- melanocytic tumors

References

- Bastian BC, Olshen AB, LeBoit PE, Pinkel D. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003 Nov;163(5):1765-70. PMID: 14578177

- Bastian BC. Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer. Oncogene. 2003 May 19;22(20):3081-6. PMID: 12789284

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