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Paneth cells

Friday 27 June 2003

Paneth’s cells

Pathology

- Paneth cell metaplasia

- Paneth cell hyperplasia
- Paneth cell carcinoma

- Paneth cell differentiation in colonic epithelial tumors

  • Paneth cell differentiation may occur in colonic epithelial neoplasms.
  • Paneth cell differentiation is common in early colonic neoplasms that develop via the conventional adenoma-carcinoma carcinogenic pathway.
  • Activation of Apc/beta-catenin/Tcf pathway may play a role in Paneth cell differentiation in human colonic neoplasms.
  • Some studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender.
  • Synchronous CRC are not associated with Paneth cell status, or a history of AA or CRC.
  • Paneth cell presence in the adenomas of distal colorectum may be a negative indicator for synchronous AA and CRC, and seems to warrant further studies.

- Paneth Cell-Like Component in Prostate Cancer

See also

- cells

Paywall references

- Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway. Joo M, Shahsafaei A, Odze RD. Hum Pathol. 2009 Jun;40(6):872-80. doi : 10.1016/j.humpath.2008.12.003 PMID: 19269007

- Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma. 2016.
https://www.nature.com/articles/srep26129