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Home > A. Molecular pathology > Targeted therapy > Therapeutical antibodies > cetuximab


Friday 24 September 2004


Definition: Cetuximab (Erbitux) is a monoclonal antibody designed to bind specifically to EGFR and block certain growth factors from binding and signaling the cell to promote tumor cell growth, survival, and progression.


- treatment of EGFR-expressing metastatic colorectal cancer

See also



- Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V, Ducreux M, Ychou M, Bibeau F, Bouché O, Reid J, Stone S, Penault-Llorca F. J Clin Oncol. 2009 Dec 10;27(35):5924-30. PMID: 19884556