- Human pathology

Home > D. General pathology > Genetic and developmental anomalies > body axes

body axes

Thursday 30 September 2004

- Axes formation and RNA localization

Axes formation in flies and frogs largely depends on RNA localization pathways functioning in the oocytes. It is thought that motors moving along the cytoskeleton enable the selective transport of RNAs to different destinations during oocyte development.

Many of the steps in RNA localization are conserved, despite the existence of a variety of mechanisms, including the formation of nuclear ribonucleoprotein complexes, and active transport along microtubules.


- Minakhina S, Steward R. Axes formation and RNA localization. Curr Opin Genet Dev. 2005 Aug;15(4):416-21. PMID: 15967657

- Meinhardt H. Models for the generation of the embryonic body axes: ontogenetic and evolutionary aspects. Curr Opin Genet Dev. 2004 Aug;14(4):446-54. PMID: 15261663