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foreign body reaction

Saturday 27 November 2004

foreign body granuloma ; foreign body response


See also : foreign-body giant cell

Definition: The foreign body granuloma is a response of biological tissue to any foreign material in the tissue. Tissue-encapsulation of an implant is part of this. An infection around a splinter is part of this, too.

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR).

FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis.

Examples of foreign body

- wood
- glass
- surgical material
- talc in intravenous drug use
- beryllium


- lung
- skin

  • dermal foreign body granuloma

- joints

Digital slides

- UI:872 - Foreign body granuloma (Foreign body reaction)


- Foreign-body giant cell reaction to suture in lower lip

- Foreign body giant cells chewing up lamellar keratin strands from a ruptured cyst.


- granulomatous inflammation
- foreign body giant cells
- foreign body splinter
- marked fibrosis and scaring
- remnants of the foreign body surrounded by multinucleated giant cells


- foreign body penetration
- cholesterol deposits (cholesterol crystals, cholesterol clefts)
- tissular calcifications (calcium deposits)

See also

- chronic inflammation