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CMV hepatitis

Wednesday 8 December 2004

Definition: CMV is the most important cause of opportunistic hepatitis in immunocompromised patients. 20% of patients with liver allograft develop CMV hepatitis.


- CMV inclusion in a portal space


- cytomegalic cytopathic effects

  • enlarged cells
  • cytomegalic nuclear inclusions
    • large, glassy masses in the nucleus, separated by a clear halo from the irregularly thickened nuclear membrane
  • cytomegalic cytoplasmic inclusions
    • basophilic or amphophilic granules of various size
  • inclusion-bearing cells maybe encircled by a cluster of neutrophils

- +/- confluent foci of hepatocellular necrosis
- unusual massive hepatic necrosis

Three clinicopathological patterns

- mononucleosis-like disease

See also

- cytomegalovirus
- CMV infections
- viral hepatitis
- Hepatitis


- Congenital CMV disease by Washington Deceit

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- Theise ND, Conn M, Thung SN. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol. 1993 Jan;24(1):103-8. PMID: 8380273